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Bioavailability is usually determined by calculating the respective plasma drug exposure assessed as the total area under the drug plasma concentration versus time curve (AUC) after oral and intravenous administration as: In general, determinants of oral drug bioavailability include fraction of dose absorbed in the gastrointestinal tract (GIT) and fraction of dose that escapes elimination by the intestinal tract, liver, and lung

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Furthermore, the concentration of GSH and the GSH/GSSG ratio vary between intracellular organelles, and this compartmentalization is actively regulated in the cell 3

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(1) The normal control group was injected with 09 % saline daily

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Peptides are compact sequences of amino acids connected through peptide bonds, functioning as the fundamental components of proteins

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