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Glucagon primarily promotes hepatic glucose production and mobilization of energy stores during fasting

Resistin-like molecule- is induced following bronchoconstriction of asthmatic airways

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By stabilizing cardiolipin in the inner mitochondrial membrane, SS-31 enhances electron transport chain efficiency and reduces oxidative stress, both of which are impaired in chronic inflammatory conditions like lupus

If used for diabetes care, consult with an endocrinologist to possibly bridge therapy to minimize the risk of hypoglycemia

The combination was first characterized for safety and pharmacokinetics in a Phase 1b trial, [4] then advanced into the Phase 3a REDEFINE program