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Ouyang H, Zhu H, Li J et al (2022) Fumonisin B(1) promotes germ cells apoptosis associated with oxidative stress-related Nrf2 signaling in mice testes

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This process leads to the suppression of ALOX15 and a consequent decrease in lipid ROS accumulation in gastric cancer cells, potentially contributing to drug resistance

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This demonstrated that ligand engagement deep within the TM core was not a requirement for class B1 GPCR activation from the extracellular face