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Journal of Biological Chemistry, 288 (35), 2508825097

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v) regardless of the presence or absence of dyslipidemia, the oxidative stress status, highlighted by the decrease of GPx, triggers lipid oxidation, with the formation of anti-LDL-oxidized antibodies, leading to the onset of vascular endothelial aggression, with early atherogenic pathology

So its almost never the case that the plaque is just squeezing the blood vessel shut