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2.24 (1.61-3.49) to 3.95 (2.69-5.37), 3.10 (2.67-4.12) to 5.03 (3.67-6.85), and 73.7 (48.8-89.1) to 71.1 (48.6-87.6), respectively

Individual response varies based on dosage, health status, and lifestyle factors

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Sensitization occurred before LPS injection (4 h, day 1 and day 3), and LPS alone neither increased nociceptor excitability nor pain behavior, indicating that cartilage autoantibodies, not LPS or arthritis itself, drive pain behavior and sensorymotor dysfunction (Extended Data Fig