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While the mechanism of action of mecobalamin against amyotrophic lateral sclerosis (ALS) is not known, it has been suggested in non-clinical research that mecobalamin may have efficacy through a neuroprotective effect and regeneration of nerve axons

Exenatide once weekly over 2 years as a potential disease-modifying treatment for Parkinsons disease: protocol for a multicentre, randomised, double blind, parallel group, placebo controlled, phase 3 trial: the Exenatide-PD3 study

In clinical trials reported on the drugs label, 15.8% of patients taking the 5 mg dose and 20.3% of patients taking the 1 mg dose reported nausea

However, more recent studies have demonstrated that the hepatic biosynthesis of AGT is the major source of renal ANG II concentrations and its renal expression depends on the integrity of the glomerular sieving function ( In fact, when the glomerular capillary wall, acting as a molecular barrier, is impaired, AGT protein is leaked into the tubular lumen and then reabsorbed at S1, S2 and S3 segments of proximal convoluted tubules ( The AGT reabsorption is a megalin-dependent process

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