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Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation

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With melanocytic nevi, on the other hand, growth is limited owing to senescence, which causes a cell to fail in its attempt to re-enter the cell cycle, thereby preventing mitosis.28 Senescence is induced by various mechanisms, thus hampering the development of uncontrollable tumors

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doi: 10.1016/j.toxlet.2005.10.018