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View in: Pubmed Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells

Quickstart Highlights Cagrilintide is a long-acting amylin analog studied for appetite control and weight management [1] it imitates the satiety hormone amylin to blunt hunger and slow gastric emptying [2]

TB-500 is related to thymosin beta-4 activity and is studied for cell migration and tissue remodeling, which are important during repair

The peptide releases directly into the gastric environment where it can exert local protective effects before degradation occurs

Ohanian M, Rozovski U, Kantarjian HM, Loghavi S, Zuang Z, Abruzzo L, Huh YO, Garcia-Manero G, Ravandi F, Andreeff M , Kornblau S, Borthakur G, Nguyen M, Hu P, Medeiros J, Nogueras-Gonzalez GM, Huang X, Estrov Z, Bueso-Ramos CE, Cortes JE