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While enhanced drug efflux, epitomized by P-glycoprotein (P-gp/ABCB1) overexpression, has long been considered the classic paradigm of MDR, clinical strategies based on the simple competitive inhibition of this target have repeatedly faltered [19, 20]

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However, the combination therapy was associated with a higher occurrence of gastrointestinal issues like nausea, with rates ranging from 20% to 47%

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Clin Pharmacol Drug Dev 12(2):202211 Fang J, She J, Lin F, Wu JC, Han R, Sheng R et al (2022) RRx-001 exerts neuroprotection against LPS-induced microglia activation and neuroinflammation through disturbing the TLR4 pathway

evaluated the essential nutrient intake in obese cats undergoing weight reduction using therapeutic diets