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Although initially considered a waste product of aerobic glycolysis (e.g., the Warburg effect), lactate has been shown to serve as the primary carbon source for the TCA cycle in vivo, providing substrates, and thus electrons, for oxidative phosphorylation in normal tissue and tumors 2,3
251 Similarly, iron chelation has been shown to enhance insulin sensitivity in the mouse liver
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Code availability The code generated for immunopeptidomics bioinformatics analysis has been deposited in the Zenodo repository under DOI:10.5281/zenodo.14496237 [ and is available under a GNU GPLv3 open-source license
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