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Additionally, variations in dosing equivalence, species-specific GLP-1 receptor expression, and metabolic responsiveness further complicate the direct translation of these findings to human diseases ( Compounding this complexity, not all preclinical studies have yielded positive outcomes

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[DOI] [PubMed] [Google Scholar] Thriault Y., Logan T

10.1146/annurev-bioeng-071516-044546 [DOI] [PubMed] [Google Scholar] Yu X., and Long Y.C

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Most other serious stomach issueslike ulcers, pancreatitis, or bleedingdid not increase with these drugs