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These effects were blunted in CNS-specific GIPR knockout mice, suggesting a key role of CNS GIPR in the control of energy metabolism (138) ( Figure 1 Section C)

Possible side effects of orlistat (Xenical/Alli) While the active ingredient orlistat which works by inhibiting the enzymes that break down fat in the gut, preventing your body from absorbing it debuted back in 1999 to a lot of fanfare, Fishman says its become less popular for two big reasons: side effects and minimal benefits. Those side effects are mostly gastrointestinal, and can include abdominal pain in up to 30% of patients

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Fried foods, heavy cream sauces, fatty cuts of meat, and high-sugar foods can cause nausea or delayed gastric emptying symptoms in some patients