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Josephine Egan and colleagues teamed with Amylin Pharmaceuticals to begin preclinical testing of exendin-4

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The concomitant improvement in insulin sensitivity and beta-cell function, which were associated with normalization of glucose levels in people with prediabetes, suggests that tirzepatide treatment may delay and potentially halt progression to T2D, by inducing so-called beta-cell rest and ultimately, modifying the natural history of prediabetes/T2D

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