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B12 and caffeine work through completely different mechanisms B12 supports cellular energy production, while caffeine blocks adenosine receptors to reduce perceived fatigue

Most are not FDA-approved for human use, some exist only through a prescription or compounding pharmacy tied to a different condition, and the rest are sold exclusively as unregulated "research chemicals" not intended for human consumption

10.1007/s00415-022-11496-y J

Macrocytic anemia is characterized by larger and fewer red blood cells

Recent research has found that mutations in the TCA cycle enzymes SDH, FH, and IDH resulted in a dysfunction of the TCA cycle and defects in mitochondrial metabolism in a wide range of human cancers [7, 8]

Nutrients 13 , 395 (2021)