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Lockrow et al

Given the role of PYY in appetite suppression it is thought that disturbances in PYY release in response to food intake may play a role in the development of obesity

In psychology, this kind of repetitive thinking is called rumination

For example, a GLP-1/oestradiol conjugate reduced food intake and body weight in different rodent models of the metabolic syndrome, displaying greater efficacy than GLP-1 alone [100]