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Initial appetite suppression appears within 37 days, but noticeable weight loss typically begins in weeks 23 and accelerates through weeks 512

Based on the current clinical trial timeline, retatrutide Phase 3 trial results are expected to be published in late 2026 or 2027

Rarely, allergic reactions (including anaphylaxis) have been reported, particularly in individuals with occupational exposure to ispaghula dust

Blunted reward responsiveness in remitted depression

Drugs like Wegovy and Zepbound are specifically approved for use in chronic weight management only

The medication itself is rarely the problem we cannot solve