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Fang J, Wang L, Wu T, Yang C, Gao L, Cai H, et al

Regular monitoring is essential for those on long-term treatment to ensure adequate replacement and prevent complications

The study was not a robust randomised, placebo-controlled pain trial and cannot establish treatment of any particular pain condition

Kim HJ, Litzenburger BC, Cui X, Delgado DA, Grabiner BC, Lin X, et al

ACTH come from a precursor molecule known as pro-opiomelanotropin (POMC) which produces several biologically active molecules when cleaved, including ACTH, melanocyte-stimulating hormone, and the brain opioid peptides known as endorphins

Current data emphasizes receptor selectivity, intracellular pathways, and broader systemic observations, but no definitive applications have been established