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Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state

Oxidative stress can increase as a result of illness, environmental toxins, poor diet and other lifestyle factors

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Lactate also protects neurons during metabolic stress and influences gene expression related to plasticity [298]

This contrasts sharply with orthobiologic therapies like PRP and mesenchymal stem cell therapies, both of which have been evaluated in multiple randomized controlled trials and large observational studies