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P =0.02)

Tirzepatide (Mounjaro) is a dual agonist, targeting both GLP-1 and GIP receptors, potentially offering enhanced weight loss benefits

It is normal to feel motivated and also a bit cautious

Once-weekly formulations (semaglutide, dulaglutide) can be injected morning or night on the same day each week, whilst twice-daily exenatide must be given within 60 minutes before main meals

Magnesium glycinate (200-400mg at night), increased water intake, and fiber help

In rodents, modulation of GLP-1R activity can influence amyloid-beta peptide aggregation in Alzheimers disease (63) and dopamine levels in Parkinson's disease (64)