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It is safe to use them if your skin is used to both of these ingredients

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ACS Pharmacol Transl Sci 6(6):868877

321-327 Chalmers, R.A., Valman

[DOI] [PubMed] [Google Scholar] Hannestad J, DellaGioia N, Bloch M (2011) The effect of antidepressant medication treatment on serum levels of inflammatory cytokines: a meta-analysis