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They frustrate everyone

The drugs also replicate the effects of the GLP-1 hormone, which is a part of the reward pathways in the brain that drive people to participate in pleasurable activities like eating food

GIP is secreted from K-cells of the proximal small intestine (duodenum and jejunum) [8,41], while GLP-1 secretion from L-cells of the small and large intestine (distal ileum and colon) [42] following an introduction of carbohydrates, triglycerides, protein, or amino acids

Merola, MD, MMSc, of the University of Texas Southwestern Medical Center and ODonnell School of Public Health, and colleagues wrote

You notice benefits faster while using lower total doses, making treatment both more effective and more efficient

I just needed eyeballs