In human skin fibroblasts, Nrf2-driven antioxidant enzyme expression translated into: Reduced intracellular ROS Improved mitochondrial membrane potential Protection against senescence-associated cell damage [36] In human gingival and periodontal stem cells, Epitalon significantly reduced aging biomarkers such as p16 and p21, decreased ROS levels, and preserved mitochondrial function, even under stress [42]
Protein concentration was determined via BCA assay before SDS-PAGE separation
Ovarian cancer-intrinsic fatty acid synthase prevents anti-tumor immunity by disrupting tumor-infiltrating dendritic cells
CM was replaced every 48 h
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