Analyzing and quantitatively detecting specific protein isoforms or active/inactive protein states
In two of the OPM-2 xenografts, BSO+L-PAM reduced tumor volumes of 1330 mm 3 and 972 mm 3 to 2), inducing CRs in majority of the mice treated (21/25), achieving MCRs in 6/25 mice, and doubling the median EFS relative to L-PAM alone ( P 80% was not cytotoxic, whereas three cell lines were affected by BSO
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This inhibition promotes the breakdown of stored fat and prevents excessive fat storage, making it a promising candidate for weight management and metabolic health
doi: 10.1007/s12016-021-08883-0 3