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The present study supports these findings, as we show that an increased kynurenine/tryptophan (Kyn/Trp) ratio, a well-established marker of inflammation [63, 78, 79], correlates with manifest disease

It has been suggested that type 2 diabetes mellitus (T2DM) may be a risk factor for PD and comorbid T2DM may worsen PD symptoms, as well as accelerate neurodegeneration