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Globally, CKD affects 8 to 16% of the population [2], and is very closely associated with adverse clinical outcomes and an increased risk of all-cause mortality [3]

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJ, Gripp KW, Mirzaa GM, Amemiya A, editors

It is is caracteristized by a prolonged exhaustion state, uneasily relieved by rest and often exacerbated by physical or intellectual effort and emotions

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