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Dilokthornsakul et al 15 reported that most adverse events were gastrointestinal tract symptoms or skin reactions

That single-molecule design is what separates it from stacking three drugs: the pharmacokinetics are unified, and the once-weekly half-life comes from a fatty-acid modification similar to the one used on semaglutide and tirzepatide

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Published research uses varying doses depending on the model and endpoint

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10c,d) and reduced AMPK expression (Extended Data Fig