Check back for more stories about the lesser-known downsides of these wildly popular medications
Classical-like EDS (type 1 cEDS) is characterized by skin hyperextensibility with velvety skin texture and absence of atrophic scarring, generalized joint hypermobility with or without recurrent dislocations (most often shoulder and ankle), and easily bruised skin or spontaneous ecchymoses (discolorations of the skin resulting from bleeding underneath)
Morton Publishing Co, 2nd Ed., 2004 Kishi T, et al, Inhibition of myocardial respiration by psychotherapeutic drugs and prevention by coenzymeQ, Biomedical and clinical aspects of coenzyme Q, Yamamura Y, Folkers K, and Ito Y, eds, Elsevier/NorthHollandBiomedical Press: Amsterdam, 1980, vol2, 129-154
While monthly GLP-1 formulations may become commercially available soon in higher-income regions, other geographies especially those with high expected biosimilar penetration may continue relying on weekly-dosed drugs for the foreseeable future
But it is one of the primary reasons that improving your metabolic health rather than just cutting calories leads to more sustainable weight management
For one, a regulatory workaround that has allowed Hims and others to sell compounded GLP-1s when brand-name forms are in shortage will expire once the FDA declares Novo Nordisk s semaglutide as readily available
