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10.3389/fonc.2022.834729 130 LinJ.-F.HuP.-S.WangY.-Y.TanY.-T.YuK.LiaoK.et al (2022)
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Zuchowski, L
The C-terminal domain contributes to structural stability and dimerization
It is possible that the cysteinyl axial ligand in cytochrome P-450 plays an important role in OO bond cleavage, and that the interactions found in catalase and peroxidase that appear to facilitate such cleavage are therefore not necessary.
It is possible that the cumulative or progressive dosing regimen contributed to the outcome, particularly given that a dose of 10 mg/kg has been associated with adverse neurological effects in other experimental settings (Mohammadpanah et al., 2023
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