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In addition, liraglutide could also induce the cell cycle arrest of vascular smooth muscle cells through the AMPK pathway, thereby delaying the formation of AS (130)

Habener drew on the skills of several young researchers

Peptide therapeutics are not naturally suited for oral administration because of their inherently low gastrointestinal permeability, high susceptibility to degradation by gastrointestinal and serum proteases, and rapid renal clearance 8

GLP-1 receptor signaling: effects on pancreatic beta-cell proliferation and survival

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GLP-1R activation has a significant effect on glycemic control in patients with T2DM through a variety of mechanisms, including stimulation of insulin secretion, inhibition of glucagon secretion, protection of -cells from apoptosis, slowing gastric emptying and increasing satiety (Drucker, 2006)