Steady State Timeline by Dose Level These timelines follow the lexicon standard titration (2mg to 4mg to 8mg to 12mg, every 4 weeks) combined with the 4-to-5-week steady-state rule
GLP-1R/GIPR dual agonists improve lipid metabolism, with greater potential than GLP-1RAs
Each 250 mcg dose equals 10 units
Neurological and Energy Headache often related to dehydration or low calorie intake Fatigue common in weeks 18, often from reduced eating rather than drug toxicity Dizziness usually mild
As your body adjusts over the first several weeks, the discomfort typically fades, making the treatment much more tolerable
Chang G, Liu J, Qin S, Jiang Y, Zhang P, Yu H, Lu K, Zhang N, Cao L, Wang Y