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To protect the environment and living conditions while promoting efficiency, restrictions are placed on the negative externalities of different uses

10.1098/rsob.190290 13 LiG.LiuJ.WangY.YangK.ZhaoM.XiaoY.et al (2017)

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When there's excessive anything in a given pathway (especially something as toxic as glutamate), the brain responds by reducing sensitivity and/or # of receptors