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En definitiva, los mecanismos de accin de insulina basal y lixisenatida son complementarios, lo que les convierte en una combinacin atractiva, fundamentalmente en aquellos pacientes en tratamiento previo con insulina basal y a los que se les debe intensificar el tratamiento, minimizando la esperada ganancia ponderal y reduciendo la mayor probabilidad de presentar hipoglucemias que tienen lugar si utilizamos una terapia basal bolo con insulina basal y anlogos de insulina rpida o una terapia de mltiples dosis con insulinas premezcladas