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Phase 2 trial data (NEJM 2023) showed approximately 17.5% mean body weight reduction at 24 weeks at the highest dose, but week-4 figures were not reported as a primary endpoint
Future studies will need to clarify whether any signal differs by menopausal status, endocrine therapy exposure, obesity phenotype, tumor subtype, or duration and timing of GLP-1 receptor agonist use
Highlights of prescribing information for Mounjaro (tirzepatide) injection [PDF]
Human specific regulation of the telomerase reverse transcriptase gene
While GH therapy (not ipamorelin) has been shown to increase lean body mass and decrease fat mass in recreational athletes [10], there is no evidence showing that ipamorelin offers these benefits
If protein intake is low and strength training is absent, the body may break down some muscle tissue in addition to fat
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