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10.3390/toxins12090558 132 JeonS.KimN.-H.KooB.-S.LeeH.-J.LeeA.-Y

Advances in patterning, materials and microfabrication techniques have enabled researchers to isolate and investigate the effects of confinement on tumor cell behavior

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Most patients describe the sensation as a brief pinch followed by mild pressure

Furthermore, while in 2D/unconfined environments breast cancer cells maintain a mesenchymal migration phenotype characterized by actin-rich protrusions and adhesion to the substrate [7], in confinement, cells switch to an amoeboid/bleb-based migration mode [152, 164, 165]