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Am J Kidney Dis (2021) 77(2):2806

Variants in the GLP1R gene (such as rs6923761), GIPR gene (rs1800437), and appetite-regulation genes like MC4R and FTO shape your individual dose-response curve

A lot of the time, what feels like a plateau is actually part of the normal pattern of weight loss, not a sign that the medication has stopped working

Safety Signals to Discuss Before Any Combination Combining medicines that reduce appetite can raise concerns about tolerability, hydration, and adequate nutrition

Long-term human safety data does not yet exist

At the moment, there are more studies from the OASIS group in development that may bring new results in weight loss