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The combination is not appropriate for Individuals with diabetes or prediabetes (the insulin resistance interaction risk is too poorly understood)

In a model of sepsis-induced neuroinflammation, hydrogen has been shown to decrease the polarization of M1-type microglia while increasing the polarization of M2-type microglia through the modulation of mTOR-autophagy-dependent pathways (Zhuang et al., 2020)

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