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Media for all experiments used high glucose DMEM (Gibco #11965084) or glucose and glutamine free DMEM (Gibco #A1443001) supplemented with 10 mM glucose and 4 mM glutamine unless otherwise indicated

It is biologically intelligent and entirely predictable

However, dry AMD is more prevalent further in turns to wet AMD when new blood vessels develop to reduce the dryness of macular layer

TXNIP: thioredoxin-interacting protein

( g ) HTML:TML ratio was assessed in FT282-CCNE1 cells treated with the IDH1 inhibitor and supplemented with KG (n = 8 technical replicates representative from 2 independent experiments)

It does not bind to androgen receptors, nor does it promote hypertrophy (growth) of healthy tissue