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It appears in human plasma at approximately 200 ng/ml in young subjects, with a drop of more than 60 % between ages 20 and 60, an observation that motivated forty years of research on its role in tissue repair, wound healing, hair growth and cutaneous longevity

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Localised Autocrine/Paracrine Activity IGF-DES produces rapid and localised IGF-1R activation with a shorter activity period

In histamine intolerance, the body cannot break down histamine efficiently, often due to low levels of diamine oxidase (DAO) enzyme or impaired methylation pathways

In addition, the clearance role of the liver is a major obstacle to gene delivery therapy