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53 In mice, exenatide promoted polarization toward the anti-inflammatory M2 phenotype, associated with tissue repair, via cyclic adenosine monophosphate (cAMP) induction, which activates protein kinase A (PKA), leading to inhibition of c-Jun N-terminal kinase (JNK) phosphorylation and enhanced activation of signal transducer and activator of transcription 3 (STAT3) (Figure 2B)

Each section draws on primary literature, peer-reviewed publications, and official clinical trial data to present an evidence-based assessment of what may be the most significant advance in obesity pharmacotherapy since the approval of injectable semaglutide for weight management

2022 Mar 18;12(1):4673

da Silva LE, de Oliveira MP, da Silva MR, et al