The middle of the chart is a fine-tuning exercise
doi:10.2147/JEP.S256586 Johnson JK, Liranso T, Saylor K, et al
Several examples, such as Nutlin-3, an inhibitor of the p53:MDM2 interaction 43 , ABT-263/Navitoclax, an inhibitor of BCL-2 family protein interactions 44 , and JQ1, which disrupts complexes of BRD4 with acetylated histones 45 , indicate that this is in principle achievable
Together they target the root cause of pigmentation-driven dark circles, not just puffiness
It is better understood as a skin-brightening and antioxidant therapy , not a permanent skin whitening solution
If youve been feeling more tired lately or seem to have trouble maintaining your weight, its easy to think you may have a thyroid problem