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10.1016/j.neuropharm.2019.107789 137 Meric-BernstamF.TannirN

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Clarifying the difference of metabolic profiles and of molecular mechanisms between HFrEF and HFpEF might provide clinical significance of carnitine metabolism as new therapeutic target for metabolic disorder in hypertensive HFpEF, remaining unmet medical needs in cardiovascular medicine

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Enzyme Induction Involving the Ah Receptor Halogenated aromatic hydrocarbons including polybrominated biphenyls, polychlorinated biphenyls, various dioxins including the potent 2,3,7,8-tetrachlorodibenzodioxin (TCDD), and dibenzylfurans, as well as the protypical inducer 3-methylcholanthrene, act by binding to the intracellular Ah receptor (AhR) (Carlson and Perdew 2002