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What Happens When You Inject Cold Semaglutide: Safety Considerations Injecting semaglutide directly from a cold refrigerator (not frozen) is generally safe, though many patients find cold injections cause temporary stinging or localized numbness at the injection site

Wegovy is the only FDA-approved semaglutide medication for treating overweight and obesity

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If different physicians prescribe each medication, patients must explicitly disclose both to each provider and request a medication review before starting Wegovy

However, some individuals may experience mild side effects, including: Nausea Diarrhea or constipation Fatigue Injection site reactions Most side effects subside over time as the body adjusts to the medication

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