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It is why patients with a personal or family history of medullary thyroid carcinoma, or Multiple Endocrine Neoplasia syndrome type 2, are excluded from GLP-1 treatment

In fact, there is a well-documented counter-regulatory reduction in metabolic rate in both humans (31, 32) and rodents (30, 33) treated with GLP-1R agonists for extended periods due to the reduction food intake