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Safety Considerations and Future Outlook As with all pharmacotherapy for obesity and T2D, establishing cardiovascular safety and demonstrating improvements in meaningful clinical outcomes will be essential, particularly as cardiovascular outcome trials have not yet been completed with multi-agonists (although data are expected soon for tirzepatide: SURPASS-CVOT [T2D] in 2025
At the same time insulin releasing function of GLP-1 has to be maintained
Results The model detected 112,274 T2D patients who did not receive insulin therapy and started GLP1-receptor agonists (28,081 individuals) or SGLT2 inhibitors (84,193 individuals) in the United Kingdom (UK) from January 2013 to October 2020
But the real story isn't the drugs themselves: it's what they're revealing about how your metabolism actually works, and why willpower was never the problem