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Then a maintenance of one injection monthly may be advised

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Some treatments may show results after a single session, while others may require a series of 2 to 6 treatments for optimal results

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Biochemically, the cobalt center can take part in both two-electron and one-electron reductive processes to access the "reduced" (B 12r , +2 oxidation state) and "super-reduced" (B 12s , +1 oxidation state) forms