Animal ethics declaration Not applicable
doi: 10.1111/jgh.13278 178
HFD feeding attenuates the lipid-lowering actions of sitagliptin
doi: 10.1080/00207454.2021.1924707 7 IqbalJWuHXHuNZhouYHLiLXiaoFet al
conducted the present pilot study [2] to examine the ratio of acylcarnitines to free carnitines (AC/FC), a biomarker of cardiomyocyte carnitine insufficiency and impaired -oxidation [3], either in symptomatic HF with reduced left ventricular ejection fraction (LVEF) HFrEF or HF with preserved LVEF (HFpEF), and demonstrated that AC/FC levels in admission were significantly higher than in asymptomatic staged HF, decreasing to comparable levels at discharge
Patients and trial participants should be aware of the following red flag symptoms that require urgent review: Dysphagia (difficulty swallowing) or odynophagia (painful swallowing) Unexplained weight loss beyond that expected from the medication Persistent vomiting or an inability to keep fluids down Haematemesis (vomiting blood) or melaena (black, tarry stools) Severe or worsening chest pain if you experience severe chest pain, particularly with breathlessness, sweating, or pain radiating to the arm or jaw, call 999 immediately , as these may indicate a cardiac emergency rather than a digestive cause Symptoms that persist despite appropriate self-management , or that significantly affect daily life These symptoms may indicate more serious conditions such as oesophagitis, peptic ulceration, or, in rare cases, upper GI pathology requiring endoscopic investigation
