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The Phase 2 trial followed participants through 48 weeks of treatment but did not include an extended washout observation period comparable to longer post-trial data available for Semaglutide

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While CBP/p300 is a well-validated direct interaction partner of NRF2 with prominent functions at enhancers, we report that this interaction is not required for NRF2-dependent NSCLC cell growth, indicating that NRF2 can sustain sufficient transcriptional activity in the absence of CBP/p300 coactivation

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Bupropion: An antidepressant and smoking cessation aid, bupropion affects neurotransmitters such as dopamine and norepinephrine

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