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ADA Standards of Care 2025 support CGM across a broader clinical spectrum, while Medicare criteria now cover all insulin-treated patients and certain non-insulin patients with documented problematic hypoglycemia

patients should use backup or non-oral contraception for 4 weeks after each dose change

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A 2025 systematic review (PMC, 36 studies, 1993-2024) found consistent improvement in tendon, ligament, muscle, and bone healing in animal models

Biomarker Assessment Before & During MIC B12 Therapy Baseline serum B12 and methylmalonic acid (MMA) levels provide objective context for whether MIC B12 therapy is appropriate