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Ethics declarations Ethics approval and consent to participate The study protocol was conducted according to the guidelines contained within the Declaration of Helsinki and was approved by the ethics committees of Yokohama City University and Kyoto Prefectural University

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As blood pressure increases, plasma levels of C-reactive protein (CRP) [206, 207]and cytokines (particularly IL-6, tumor necrosis factor (TNF) [208, 209], and IL-1, IL-18, and CC chemokine ligand 2 (CCL2) also elevate [210,211,212,213]

Neurological Symptoms Brain fog Headaches Dizziness Insomnia Irritability and mood swings 3

We loved our experience joked that we wished we had booked them for an additional day of our trip because we felt so recharged

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