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American Journal of Lifestyle Medicine, 12(6), 499512

(Cambridge, United Kingdom: Global Phasing Ltd

GLP-1 receptor activation enhances glucose-dependent insulin secretion from pancreatic beta cells, suppresses inappropriate glucagon release, slows gastric emptying, and reduces appetite through central nervous system pathways

Clinical trials show approximately 25 to 39% of weight lost on semaglutide comes from lean body mass, but much of that is liver volume reduction and body water, not skeletal muscle

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